Bukoba can be reached through Dar es Salaam at Julius Nyerere International Airport or Arusha through Kilimanjaro International Airport. From both Arusha and Dar es Salaam, there are local flights by Air Tanzania and Precision Air to Bukoba Airport, with a brief stopover in Mwanza at the southern shore of Lake Victoria.
An alternative travel arrangement is through Entebbe International Airport just across the border in Uganda. Road travel between Entebbe/Kampala and Bukoba is about 300 km and may require a transit visa through Uganda depending on your nationality.